Recombinant human bone morphogenetic protein-2와 anorganic bovine bone 혼합이식 후치유과정에 관한 실험적 연구
Experimental study on healing procedure after combined grafting of recombinant human bone morphogenetic protein-2 and anorganic bovine bone
안교진, 박주철, 김영균,
소속 상세정보
안교진 ( Ahn Gyo-Jin ) - 분당서울대학교병원 치과 구강악안면외과
박주철 ( Park Ju-Cheol ) - 서울대학교 치의학대학원 구강조직학교실
김영균 ( Kim Young-Kyun ) - 분당서울대학교병원 치과 구강악안면외과
KMID : 0353320140380020083
Abstract
Purpose: The purpose of this study was to evaluate a bone healing procedure using anorganic bovine bone and recombinant human bone morphogenetic protein-2 (rhBMP-2).
Materials and Methods: Anorganic bovine bone (Bio-Oss®; Geistlich Pharma AG, Wolhausen, Switzerland) was grafted at two preformed alveolar bone defects in beagle dogs. One was filled only with Bio-Oss® while the other was filled with Bio-Oss® mixed with rhBMP-2. Both animals were sacrificed at 2, 4, and 8 weeks after the experiment. Block specimens, including grafted bone and surrounding bone, were harvested and histological healing procedure evaluated.
Results: Increased strength and radiopacity were observed in both groups in a time-dependent manner. However, when using rhBMP-2 together, more new and matured bone was formed histologically.
Conclusion: In this study, we showed that rhBMP-2 can promote bone formation effectively, and anorganic bovine bone can be used as a scaffold.
키워드
Bio-Oss; Recombinant human bone morphogenetic protein-2; Scaffold
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